Staci is a writer living in Atlanta, Georgia. When not writing, she spends most of her time trying to keep up with her four rescue cats and Australian shepherd puppy.

Great Dane Mastiff Mix

Jul 22 ·
great dane mastiff mix

When people think of large dogs, their mind instantly goes to a Great Dane. If you’re looking for a large dog and want some Great Dane in there thanks to their sweet and gentle nature, why not consider a Great Dane Mastiff mix? They are commonly known as the Daniff.

If you’re thinking about it, here’s everything you need to know about them, from cost to veterinary needs.

Where To Get A Great Dane Mastiff Mix

The most obvious place to get this mix is a breeder. It’s important, however, to look for an ethical one. AKC registration is what those seeking a purebred dog should look for but with designer breeds, this gets trickier. The AKC doesn’t register mixed breeds, so it’s more difficult to tell if the breeder is legitimate. This is Ghost…

Here are the things you can look for to decide:

  • A spay/neuter contract to ensure the breeder isn’t creating backyard breeders
  • A guarantee to take them back if anything goes wrong or you can no longer care for them
  • A health guarantee
  • Openness when asking questions
  • Good reviews and references from previous puppy owners

However, a breeder isn’t your only option. Because these dogs are so large, some end up in shelters and with rescues when they grow up and the owner realizes they can no longer handle them. Before seeking out a breeder, it’s worth checking your local shelters and rescues.

The Cost

Although mixed breed dogs are often cheaper than purebred dogs, these dogs can run up to $1500 because they’re a designer breed.

If you adopt from a shelter, the cost will be significantly lower and will often include shots, microchipping, and spaying/neutering. Usually, the cost is just to cover this, though it’s always higher for puppies than adult dogs. Via…

Great Dane Mastiff Mix Veterinary Needs

Vets should deworm puppies and give them shots every three weeks until they’re sixteen to eighteen weeks old. This is important because diseases like parvovirus and distemper can infect the puppy otherwise and make them seriously ill, or even kill them. After all of these shots, they’ll get their rabies vaccine and any other optional shots, such as bordetella. This prevents kennel cough.

Large breeds can be prone to things like hip dysplasia so while staying up to date on your pet’s check-ups every year, you’ll want to look out for this. Pet insurance is always a good idea, but make sure it covers the things your pet is predisposed to. Some policies won’t cover genetic issues. Always read the fine print!

You should also stay up to date with flea and tick prevention for your dog. Usually, this is a pill or topical solution they take once a month to keep them flea and tick-free. This is Arlo…

Appearance And Temperament

These are large dogs with short coats, and very powerful. Although they can have great temperaments, the sheer physical size and strength can often make them difficult to handle, so make sure you’re cut out for them.

These breeds are both good-natured, so chances are, you’ll end up with a good-natured dog. They do have high exercise needs and you’ll need to provide them with a lot of enrichment and mental stimulation. When raised right, they’ll make a loyal and protective companion.

The most important thing you can do for your dog is to get in there early with training and socialization to shape their personality. Even before they’re fully vaccinated, you can take them places and let them view the world as long as they don’t interact with other dogs. Exposing them to things is as important as them meeting other dogs.


The most important thing to remember is that you should avoid foods that advertise as being grain-free, because it has been linked to heart disease in dogs.

Otherwise, what you feed your dog is your choice. Some people love raw diets, and there are great health advantages to these.

People do tend to make a big raw feeding mistake though: they try to do it themselves without consulting an expert. This often means the dog doesn’t get the nutrients they need, because the person hasn’t done any research.

The good news is, there are subscription services that can offer raw diets.

Dry kibble tends to be more convenient. That doesn’t mean you don’t have to do your research on this though, as some food is more filler than nutrients. Just make sure to look up the ingredients and check it’s all good for your dog. Alfie…


The good news is, the grooming needs of these dogs are pretty low in comparison to their purebred or long-haired friends! They have short coats, which means they don’t need to be brushed or bathed very much at all. Over-bathing can actually harm your dog and give them skin issues (though you can use wipes in the interim between baths).

You should, however, make sure their ears and teeth are cleaned on a regular basis. Trimming their nails every six to eight weeks is also very important, as long nails can end up being very painful. The rule is, if their nails are tapping on the floor, they need to be trimmed.

So, if you’ve decided on a Great Dane Mastiff mix, congratulations! These dogs are large and powerful, but don’t let that intimidate you or put you off. With a good owner and appropriate training and stimulation, they’re loyal and protective companions who will listen to your every word.

Great Dane Mastiff (Daniff) – Photos


great dane mastiff mix

great dane mastiff mix


great dane mastiff mix

The Bully…

Staci is a writer living in Atlanta, Georgia. When not writing, she spends most of her time trying to keep up with her four rescue cats and Australian shepherd puppy.
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